Rejuran Healer: What Polynucleotides Actually Do for Skin (Evidence Review)

Quick answer: Rejuran Healer is an injectable made from polynucleotides (PN), purified DNA fragments derived from salmon. Lab and small clinical studies suggest PN supports tissue repair, reduces inflammation and improves skin hydration, elasticity and texture over a course of treatments. The evidence is promising but still limited in size and independence, so expect gradual improvement in skin quality rather than lifting or volume.

What is Rejuran Healer?

Rejuran is made by PharmaResearch, a Korean company, and is approved in Korea as an injectable medical device. It is one of the best-known Korean "skin boosters", injected as many tiny droplets across the face. The product line includes Rejuran Healer for overall skin quality, Rejuran i for the delicate under-eye area, Rejuran S for scars and Rejuran HB, which adds hyaluronic acid and lidocaine for comfort.

What are polynucleotides?

Polynucleotides are chains of nucleotides, the building blocks of DNA. In Rejuran they come from salmon DNA that has been purified and processed. PN is closely related to PDRN (polydeoxyribonucleotide), which has a longer history in wound-healing medicine. The main difference is that PN uses longer chains, which form a gel-like structure in tissue.

What does the evidence say?

Research to date points to several mechanisms:

Tissue repair: PDRN and PN act on adenosine A2A receptors, which are involved in healing, new blood vessel growth and reduced inflammation.
Fibroblast support: lab studies show increased fibroblast activity and collagen production.
Hydration: the PN gel binds water in the dermis, which contributes to the "glow" patients report.

Clinical studies, mostly from Korea and Italy, report improvements in elasticity, fine lines, pore appearance and acne scars after a series of sessions. Most trials are small, short and some are industry-funded. That does not mean the treatment does not work. It means results vary and the size of the effect is not yet well established.

Who is it for?

Dull, tired or dehydrated skin
Fine lines, rough texture and enlarged-looking pores
Thin or sensitive skin, including recovery after lasers
Early, shallow acne scarring (often with Rejuran S)

It is not a filler and does not lift. Avoid it if you are allergic to fish or salmon proteins, are pregnant or breastfeeding, or have an active skin infection.

How the treatment works

Numbing: cream for 30 to 40 minutes. Rejuran is known as one of the more uncomfortable skin boosters.
Injection: many small blebs across the face, usually 2 cc for a full face. Some clinics use a device or cannula.
Time: about 15 to 30 minutes of injecting.

Downtime

Small raised bumps appear at each injection point and usually settle within one to three days. Mild redness and occasional pinpoint bruising are common. Most people wear makeup the next day. If you are travelling, plan Rejuran at least two days before an important event.

How many sessions do you need?

The usual protocol is three to four sessions two to four weeks apart, then maintenance every few months. One session can improve hydration and glow, but texture and fine-line changes need a series. For visitors on short trips, ask whether a single session is still worthwhile for your goals.

Price

Rejuran is usually priced per syringe (2 cc) per session, with package prices for three or four sessions. Rejuran i and Rejuran HB are priced separately. See our price guide for current KRW ranges, and confirm whether the price includes numbing and VAT.